TL;DR
- Methadone does not always appear on standard drug tests.
- Specialized panels are usually required to detect methadone.
- Methadone may stay in the system for several days or longer.
- Detection depends on the type of test used.
- Always disclose prescribed medications when required.
Whether methadone shows up on a drug test depends on the specific panel being used.
Does Methadone Come Up on a Drug Test?
Methadone can come up on a drug test, but not all drug screens automatically test for it.
Standard 5-panel drug tests often screen for substances like:
- Marijuana
- Cocaine
- Amphetamines
- Opiates
- PCP
Methadone is a synthetic opioid and is chemically different from many traditional opiates. Because of this, it usually requires a specific methadone drug test panel to be detected.
If a test includes methadone in its screening panel, it may appear as MTD on a drug screen.

Does Methadone Show Up on a Drug Test Every Time?
Not necessarily.
Whether methadone shows up depends on:
- The type of drug test used
- The purpose of the test
- The testing panel requested
- The timing of the test
For example, an MTD drug test or expanded opioid panel may specifically look for methadone. A standard workplace test may not.
If someone is prescribed methadone as part of a treatment program, they should follow employer or testing guidelines regarding disclosure.
How Long Does Methadone Stay in Your System?
How long methadone stays in your system varies based on several factors, including:
- Dosage
- Frequency of use
- Metabolism
- Body composition
- Overall health
In general:
- Methadone may be detectable in urine for several days after the last dose.
- In some cases, it may be detectable for a week or longer.
- Blood and saliva detection windows are typically shorter.
- Hair testing may detect methadone for a much longer period.
Because methadone has a long half-life, it tends to remain in the body longer than many other opioids.

What Is an MTD Drug Test?
An MTD drug test refers to a screening that specifically checks for methadone. On lab results, methadone may be abbreviated as:
- MTD
- Methadone
An MTD on drug screen result indicates that the panel includes testing for methadone or its metabolites.
These tests are often used in:
- Treatment programs
- Pain management settings
- Legal or court-related monitoring
- Expanded employment screenings
Can You Fail a Drug Test for Prescribed Methadone?
If methadone is prescribed as part of medication-assisted treatment or pain management, it may still appear on a methadone drug test.
However, most formal drug testing programs allow individuals to provide documentation of legally prescribed medications. A medical review officer typically verifies prescriptions before final results are reported.
It is important to follow testing procedures and disclose prescriptions only when instructed to do so by the testing authority.
Does Methadone Show Up as an Opiate?
Methadone usually does not trigger a positive result on standard opiate screens because it is synthetic and chemically distinct.
However, specialized panels may detect:
- Methadone itself
- Its primary metabolite
This is why asking what substances are included in the drug test panel can be helpful.
Frequently Asked Questions
Will Methadone Show Up on a 5-Panel Drug Test?
Typically, no. Most 5-panel tests do not include methadone unless specifically added.
How Long Does Methadone Stay Detectable in Urine?
Methadone may be detectable in urine for several days and sometimes longer depending on individual factors.
What Does MTD Mean on a Drug Screen?
MTD on drug screen usually stands for methadone and indicates that the panel includes testing for it.
Final Thoughts
Whether methadone comes up on a drug test depends largely on the type of test being used. Standard panels may not detect it, while expanded or specialized panels often do.
If you are prescribed methadone or undergoing treatment, it is important to understand the testing requirements involved and consult with a qualified healthcare provider or testing administrator for guidance.
