Benzodiazepine detox. Chronic benzodiazepine dependence is one of the most clinically dangerous withdrawals we manage — abrupt discontinuation can cause life-threatening seizures. On admission we perform a detailed use history (which benzo, daily dose, duration of use, prior taper attempts) and convert the daily dose to a long-acting equivalent, most commonly diazepam (Valium) using published equivalence tables. Structured taper follows: typically 10 to 25% dose reduction per week, with slower reductions in the final third of the taper where GABA-receptor down-regulation makes symptoms most persistent. The residential detox typically covers the first 7 to 14 days of taper with outpatient continuation to complete the process. Seizure precautions remain in effect throughout.
Stimulant detox. Cocaine, methamphetamine, and amphetamine withdrawal are medically less dangerous than alcohol or benzodiazepine withdrawal but psychiatrically demanding. The "crash" — profound fatigue, hypersomnia, anhedonia, dysphoria — begins within hours of last use and typically lasts 2 to 5 days. Emerging suicidal ideation is common, particularly in patients with a co-occurring depressive disorder. Protocol focus is on sleep restoration with non-habit-forming agents (trazodone, hydroxyzine, mirtazapine), aggressive nutritional and IV repletion (rehydration, electrolytes, B-vitamins, magnesium), close psychiatric monitoring with formal suicide risk assessment at admission and daily, and initiation of any indicated psychiatric medication management. There are no FDA-approved medications for stimulant use disorder yet, though bupropion, mirtazapine, topiramate, and modafinil are used off-label in selected patients.
Marijuana detox. Cannabis withdrawal syndrome — recognized in DSM-5 — includes irritability, sleep disturbance, decreased appetite, restlessness, depressed mood, and physical symptoms (headache, sweating, chills). It is not medically dangerous but can be significant enough to drive early relapse if untreated. Symptomatic management with hydroxyzine or trazodone for insomnia, supportive care, mindfulness training, and CBT for cannabis use disorder are the mainstays.
Polysubstance detox. Most patients arriving for drug detox use more than one substance. Polysubstance protocols address each substance simultaneously with its appropriate medication class, careful attention to drug interactions (particularly QT-prolongation with combined agents), and prioritized management of the most medically dangerous withdrawal first. Alcohol and benzodiazepine withdrawal are treated with immediate benzodiazepine dosing; opioid withdrawal is addressed with buprenorphine or comfort medication; stimulant psychiatric symptoms are treated with supportive and pharmacologic care.